Business Description
Seres Therapeutics, Inc. is a pioneering microbiome therapeutics firm dedicated to engineering bacterial consortia that modulate host cells and tissues to combat various diseases. Their flagship therapeutic, SER-109, an oral microbiome treatment, has successfully concluded Phase III clinical trials for the management of Clostridioides difficile infection (CDI). The company's pipeline further encompasses SER-155, a synthetically cultured bacterial formulation currently undergoing Phase Ib evaluation. This candidate aims to mitigate the risk of gastrointestinal and bloodstream infections, alongside graft-versus-host disease, in vulnerable patients undergoing allogeneic hematopoietic stem cell or solid organ transplantation. Additionally, Seres Therapeutics is advancing SER-287 and SER-301, both in Phase Ib for ulcerative colitis, as well as SER-401, which targets metastatic melanoma, and SER-262, also directed at Clostridioides difficile infection. Seres maintains strategic alliances through licensing and collaboration agreements with entities such as Nestec Ltd. and Memorial Sloan Kettering Cancer Center. Established in 2010, the company previously operated as Seres Health, Inc. before adopting its current name in May 2015, and it maintains its principal offices in Cambridge, Massachusetts.
Business History
Price Overview
Price History (1 Year)
Revenue & Net Income Trend
| Period | Revenue | Net Income | Net Margin | YoY/QoQ |
|---|
Key Metrics
EPS (Diluted): 0.64
Total Equity: $44.22M
Shares: 8,869,742
Total Debt: $10.39M
Cash: $45.77M
EBITDA: $9.83M
Total Debt: $10.39M
Cash: $45.77M
Revenue: $789,000
Revenue: $789,000
Revenue: $789,000
Total Equity: $44.22M
Tax Rate: 0.0%
Equity: $44.22M
Total Debt: $10.39M
Cash: $45.77M
Current Liabilities: $19.32M
Long-Term Debt: $0.00
Total Debt: $10.39M
Total Equity: $44.22M
Shares: 8,869,742
Shares: 8,869,742
CapEx: -$252,000
Shares: 8,869,742
Stock Price: $7.74
Net Income: $5.70M
Industry Benchmarks
Deep Analysis
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Income Statement (Annual)
Last updated: Jul 5, 2026 4:11am (just now)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Revenue | $144.9M | $0 | $0 | $0 | $789,000 |
| Cost of Revenue | $0 | $0 | $19.3M | $3.5M | $4.1M |
| Gross Profit | $144.9M | $0 | -$19.3M | -$3.5M | -$3.3M |
| Operating Expenses | $209.4M | $179.9M | $175.8M | $117.8M | $90.6M |
| Operating Income | -$64.5M | -$179.9M | -$195.1M | -$121.3M | -$94.0M |
| Net Income | -$65.6M | -$250.2M | -$113.7M | -$146.6M | $5.7M |
| EBITDA | -$56.7M | -$170.9M | -$181.4M | -$120.3M | $9.8M |
| EPS | $-14.30 | $-46.29 | $-17.77 | $-18.86 | $0.64 |
| EPS (Diluted) | — | — | — | — | — |
Balance Sheet (Annual)
Last updated: Jul 5, 2026 4:11am (just now)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Cash & Equivalents | $180.0M | $163.0M | $128.0M | $30.8M | $45.8M |
| Total Current Assets | $303.6M | $194.8M | $175.4M | $38.7M | $49.4M |
| Total Assets | $354.9M | $348.8M | $358.6M | $139.8M | $138.2M |
| Current Liabilities | $82.3M | $85.6M | $98.7M | $41.2M | $19.3M |
| Long-Term Debt | $24.6M | $50.6M | $101.5M | $0 | $0 |
| Total Liabilities | $223.4M | $338.0M | $403.5M | $126.0M | $94.0M |
| Total Equity | $131.5M | $10.8M | -$44.9M | $13.8M | $44.2M |
| Retained Earnings | -$614.4M | -$864.5M | -$978.2M | -$978.1M | -$972.4M |
Cash Flow (Annual)
Last updated: Jul 5, 2026 4:11am (just now)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Operating Cash Flow | $6.7M | -$228.8M | -$117.4M | -$148.6M | $1.1M |
| Capital Expenditure | -$9.6M | -$9.8M | -$8.0M | $-380,000 | $-252,000 |
| Free Cash Flow | -$2.9M | -$238.6M | -$125.3M | -$149.0M | $865,000 |
| Acquisitions (net) | $0 | -$92.2M | $0 | $0 | $210,000 |
| Debt Repayment | — | — | — | — | — |
| Dividends Paid | — | — | — | — | — |
| Stock Buybacks | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | $72.0M | -$16.8M | -$35.1M | -$96.7M | $15.0M |
Analyst Estimates (Annual)
Last updated: Jul 5, 2026 4:11am (just now)| Metric | 2026 | 2027 | 2028 | 2029 |
|---|---|---|---|---|
| Revenue |
$12.9M $8.7M – $17.0M
|
$358,000 $243,180 – $472,819
|
$358,000 $243,180 – $472,819
|
$249,644 $169,576 – $329,711
|
| EBITDA |
$9.3M $6.3M – $12.3M
|
$258,377 $175,509 – $341,245
|
$258,377 $175,509 – $341,245
|
$180,174 $122,387 – $237,960
|
| Net Income |
-$81.4M -$94.4M – -$38.9M
|
-$58.3M -$82.6M – -$34.0M
|
-$103.1M -$143.4M – -$59.0M
|
-$78.1M -$110.6M – -$45.5M
|
| EPS | — | — | — | — |
Growth Trends (YoY %)
Last updated: Jul 5, 2026 4:11am (just now)| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Revenue Growth | -100.0% | — | — | — |
| Gross Profit Growth | -100.0% | — | +81.7% | +5.3% |
| Operating Income Growth | -179.0% | -8.4% | +37.8% | +22.5% |
| Net Income Growth | -281.5% | +54.5% | -28.9% | +103.9% |
| EBITDA Growth | -201.4% | -6.1% | +33.7% | +108.2% |
Insider Trading (Recent)
All SEC Form 4 codes
- P Purchase
- Open-market or private purchase of shares.
- S Sale
- Open-market or private sale of shares.
- A Award / grant
- Grant or award of securities (RSUs, options, etc.) under Rule 16b-3.
- D Return to issuer
- Securities disposed back to the company under Rule 16b-3.
- F In-kind (tax)
- Shares withheld or delivered to pay the option-exercise price or tax — not an open-market sale.
- I Discretionary
- Discretionary transaction under an employee plan — Rule 16b-3(f).
- M Option exercise
- Exercise or conversion of a derivative (option/RSU) into shares — exempt.
- C Conversion
- Conversion of a derivative security into the underlying shares.
- E Short expiration
- Expiration of a short derivative position.
- H Long expiration
- Expiration or cancellation of a long derivative position with value received.
- O OTM exercise
- Exercise of an out-of-the-money derivative.
- X ITM exercise
- Exercise of an in-the-money or at-the-money derivative.
- G Gift
- Bona fide gift of securities.
- L Small acquisition
- Small acquisition under Rule 16a-6.
- W Inheritance
- Acquisition or disposition by will or the laws of descent.
- Z Voting trust
- Deposit into or withdrawal from a voting trust.
- J Other
- Other acquisition or disposition (explained in a Form 4 footnote).
- K Equity swap
- Transaction in an equity swap or similar instrument.
- U Tender / buyout
- Disposition via tender of shares in a change-of-control transaction.
Compensation-plan codes (A, D, F, M) are routine and rarely directional. Open-market P (buy) and S (sale) carry the most signal.
| Date | Insider | Type | Shares | Price | Value |
|---|---|---|---|---|---|
| 2026-07-01 | Berenson Stephen | A-Award | 7,508.00 | $7.94 | $59,614 |
| 2026-07-01 | Rosiello Robert L. | A-Award | 7,508.00 | $7.94 | $59,614 |
| 2026-07-01 | Ausiello Dennis A | A-Award | 7,508.00 | $7.94 | $59,614 |
| 2026-05-15 | Shaff Eric D. | M-Exempt | 722.00 | $0.00 | $0 |
| 2026-05-18 | Shaff Eric D. | S-Sale | 259.00 | $7.53 | $1,950 |
| 2026-05-15 | DesRosier Thomas | M-Exempt | 244.00 | $0.00 | $0 |
| 2026-05-18 | DesRosier Thomas | S-Sale | 79.00 | $7.53 | $595 |
| 2026-05-15 | Shaff Eric D. | M-Exempt | 331.00 | $0.00 | $0 |
| 2026-05-15 | Shaff Eric D. | M-Exempt | 391.00 | $0.00 | $0 |
| 2026-05-15 | DesRosier Thomas | M-Exempt | 111.00 | $0.00 | $0 |
| 2026-05-15 | DesRosier Thomas | M-Exempt | 133.00 | $0.00 | $0 |
| 2026-05-15 | Brady Kelly | M-Exempt | 180.00 | $0.00 | $0 |
| 2026-05-18 | Brady Kelly | S-Sale | 59.00 | $7.53 | $444 |
| 2026-05-15 | Henn Matthew R | M-Exempt | 238.00 | $0.00 | $0 |
| 2026-05-18 | Henn Matthew R | S-Sale | 77.00 | $7.53 | $580 |
| 2026-05-15 | Henn Matthew R | M-Exempt | 97.00 | $0.00 | $0 |
| 2026-05-15 | Brady Kelly | M-Exempt | 91.00 | $0.00 | $0 |
| 2026-05-15 | Henn Matthew R | M-Exempt | 141.00 | $0.00 | $0 |
| 2026-05-15 | Brady Kelly | M-Exempt | 89.00 | $0.00 | $0 |
| 2026-03-04 | Brady Kelly | A-Award | 56,250.00 | $9.13 | $513,563 |
Narrative Economics
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