Healthcare · Biotechnology
Price
$25.77
Market Cap
$541.2M
Employees
16
Beta
1.35
Avg Volume
10,648
CEO
Steven M. Fruchtman
Business Description
Onconova Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, focused on identifying and advancing innovative therapeutic solutions for oncological diseases. The company's pipeline currently highlights two primary drug candidates undergoing clinical trials: 1. Narazaciclib (ON 123300): This is a multi-targeted kinase inhibitor being evaluated in Phase I studies. It targets both solid tumors and hematological malignancies, with assessments as a standalone agent or in combination with other anti-cancer treatments. 2. Oral Rigosertib: This compound is in Phase I/IIa trials. It is being investigated, either alone or alongside a PD-1 inhibitor, for the treatment of progressive non-small cell lung cancer that carries K-Ras mutations. Additionally, Onconova is backing a Phase Ib/II investigator-sponsored study (ISS) examining rigosertib as a monotherapy for patients suffering from advanced squamous cell carcinoma associated with recessive dystrophic epidermolysis bullosa. Rigosertib is also undergoing preclinical development for COVID-19, available in both intravenous and oral formulations. To support its endeavors, Onconova Therapeutics has forged several strategic alliances, including a licensing agreement with SymBio Pharmaceuticals Limited. It also holds a comprehensive license, development, and commercialization pact with Pint International SA. Furthermore, the company has a collaborative licensing deal with HanX Biopharmaceuticals, Inc. specifically for the development, regulatory registration, and market release of narazaciclib. Established in 1998, Onconova Therapeutics, Inc. maintains its corporate headquarters in Newtown, Pennsylvania.
Business History
Price Overview
Last updated: Jun 27, 2026 8:02am (just now)$25.77
-3.56 (-12.14%)
Day Range
$24.65 – $26.53
52-Week Range
$24.30 – $30.54
50-Day MA
$26.91
200-Day MA
$26.91
Volume
5,235.00
Share Structure
Outstanding
21,001,663.00
Float
20,836,222.00
Free Float
99.2%
High free float
— 99.2% of shares trade freely, ~0.8% held by insiders/institutions
Very liquid — most shares trade freely. Low insider ownership can mean less management alignment, but makes large position sizing straightforward.
Price History (1 Year)
Revenue & Net Income Trend
The directional story — useful even when net income is negative.
Revenue
The top line — total sales before any costs or taxes are subtracted. A measure of how much business the company is doing.
Net Income
The bottom line — profit left after subtracting all expenses, interest, and taxes from revenue. Reflects accounting profitability, but includes non-cash items like depreciation, so it isn't the same as cash earned.
Operating Cash Flow
The real cash generated by the day-to-day business — selling products, paying suppliers, collecting from customers. Calculated from net income by adding back non-cash items and adjusting for timing (unpaid bills, unsold inventory). When OCF consistently lags net income, the reported profit may not be converting to real money.
| Period | Revenue | Net Income | Net Margin | YoY/QoQ |
|---|
Key Metrics
API Direct from provider
CALC Derived from statements
P/E Ratio (Price per dollar of earnings)
CALCStock Price / EPS (Diluted)
31.05
Stock Price: $25.77
EPS (Diluted): 0.83
EPS (Diluted): 0.83
P/B Ratio (Price vs net asset value)
APIStock Price / Book Value Per Share
-0.01
Stock Price: $25.77
Total Equity: -$629.00M
Shares: 8,376,380
Total Equity: -$629.00M
Shares: 8,376,380
EV/EBITDA (Total value vs operating profit)
APIEnterprise Value / EBITDA
-0.31
Market Cap: $541.18M
Total Debt: $0.00
Cash: $3.82B
EBITDA: $61.00M
Total Debt: $0.00
Cash: $3.82B
EBITDA: $61.00M
Enterprise Value (Takeover price (cap + debt - cash))
APIMarket Cap + Total Debt - Cash
-$3.8B
Market Cap: $541.18M
Total Debt: $0.00
Cash: $3.82B
Total Debt: $0.00
Cash: $3.82B
Gross Margin (Revenue left after direct costs)
APIGross Profit / Revenue
0.0%
Gross Profit: $0.00
Revenue: $2.79B
Revenue: $2.79B
Operating Margin (Revenue left after all operations)
APIOperating Income / Revenue
-640.7%
Operating Income: -$17.88B
Revenue: $2.79B
Revenue: $2.79B
Net Margin (Revenue left as actual profit)
APINet Income / Revenue
0.3%
Net Income: $9.17M
Revenue: $2.79B
Revenue: $2.79B
ROE (Profit from shareholder equity)
APINet Income / Total Equity
489.9%
Net Income: $9.17M
Total Equity: -$629.00M
Total Equity: -$629.00M
ROIC (Profit from all invested capital)
APINOPAT / Invested Capital
283.3%
Operating Income: -$17.88B
Tax Rate: 0.0%
Equity: -$629.00M
Total Debt: $0.00
Cash: $3.82B
Tax Rate: 0.0%
Equity: -$629.00M
Total Debt: $0.00
Cash: $3.82B
Zero debt — invested capital = equity minus cash (very efficient)
Current Ratio (Can it pay short-term bills)
APICurrent Assets / Current Liabilities
0.72
Current Assets: $7.98B
Current Liabilities: $11.15B
Current Liabilities: $11.15B
Debt/Equity (Leverage — debt vs equity)
CALCTotal Debt / Total Equity
0.00
Short-Term Debt: $0.00
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: -$629.00M
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: -$629.00M
Zero debt — this company carries no debt obligations. Strongest possible score.
Rev/Share (Top-line per share)
CALCRevenue / Shares Outstanding
$333.08
Revenue: $2.79B
Shares: 8,376,380
Shares: 8,376,380
Book Value/Share (Net assets per share)
CALC(Total Assets - Total Liabilities) / Shares
$-75.09
Total Equity: -$629.00M
Shares: 8,376,380
Shares: 8,376,380
FCF/Share (Real cash generated per share)
CALC(Operating Cash Flow + CapEx) / Shares
$-2,170.99
Operating CF: -$18.19B
CapEx: $0.00
Shares: 8,376,380
CapEx: $0.00
Shares: 8,376,380
Div Yield (Annual income from holding)
APILast Annual Dividend / Stock Price
0.0%
Last Dividend: N/A
Stock Price: $25.77
Stock Price: $25.77
Payout Ratio (Earnings paid out as dividends)
Dividends Paid / Net Income
—
Dividends Paid: N/A
Net Income: $9.17M
Net Income: $9.17M
Dividends paid not available in cash flow statement
Industry Benchmarks
Compares ONTX against LLM-researched typical ranges for its
industry. One research call per industry, cached indefinitely — every stock in the same industry
reuses the same baseline.
Deep Analysis
Pre-flight intelligence scans the company first, then routes to the right analytical methods.
0
Company Classification
— What type of company is this?
1
Industry Landscape
— Where is the industry headed?
2
Company Momentum
— Where is this company trending?
3
Forward Projection
— 1Y & 2Y projected metrics (requires Layer 1 + 2)
4a
DCF Valuation
— Present value of future cash flows
4b
Earnings Power Value
— Floor value — worth with zero growth
4c
Anchored PE
— Industry PE adjusted for growth differential
4d
Reverse DCF
— What growth is the market pricing in?
4e
Revenue-Based DCF
— For growth/narrative companies (skip if mature earner)
4f
Anchored P/S
— Price-to-Sales peer comparison (skip if mature earner)
4g
Scenario Analysis
— Bull / Base / Bear (skip if mature earner)
4h
Dividend Discount Model
— For dividend/income stocks only
4i
Book Value Analysis
— For deep value / turnaround stocks only
4j
Insider Activity
— Are insiders buying or selling?
4f
Cash Flow Quality
— How trustworthy is the FCF?
4g
Debt Maturity Risk
— Can it handle its debt?
4h
Macro Environment
— Rates, market valuation, volatility
4i
Sector Intelligence
— How does this company compare within its sector?
4j
Revenue Confidence
— How reliable is the growth projection?
4k
Sensitivity Analysis
— How fragile is the fair value estimate?
4l
Sector Demand Cycle
— Is the sector in a boom, steady state, or contraction?
5
AI Investigation
— Adaptive research engine (Claude)
5b
Thesis Evaluation
— What does the market believe? (narrative/platform stocks only)
6
Valuation Synthesis
— Weighted verdict from all methods (requires Layer 4)
Income Statement (Annual)
Last updated: Jun 27, 2026 12:02am (7h ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Revenue | $226,000 | $226,000 | $226,000 | $226,000 | $2.8B |
| Cost of Revenue | $14,000 | $14,000 | $0 | $0 | $0 |
| Gross Profit | $226,000 | $212,000 | $0 | $0 | $0 |
| Operating Expenses | $16.7M | $19.9M | $20.5M | $25.1M | $20.7M |
| Operating Income | -$16.5M | -$19.6M | -$20.3M | -$142.4M | -$17.9B |
| Net Income | -$15.8M | -$18.3M | -$18.9M | -$1.7M | $9.2M |
| EBITDA | -$16.5M | -$19.0M | -$20.3M | $1,200 | $61.0M |
| EPS | $-0.94 | $-0.88 | $-0.90 | $-10.72 | $0.83 |
| EPS (Diluted) | — | — | — | — | — |
Balance Sheet (Annual)
Last updated: Jun 27, 2026 12:02am (7h ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Cash & Equivalents | $55.1M | $38.8M | $20.8M | $21.3M | $3.8B |
| Total Current Assets | $55.4M | $39.3M | $22.7M | $25.0M | $8.0B |
| Total Assets | $55.5M | $39.4M | $22.7M | $25.0M | $10.6B |
| Current Liabilities | $6.1M | $8.0M | $9.2M | $11.5M | $11.1B |
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $9.4M | $11.1M | $12.0M | $56.6M | $11.2B |
| Total Equity | $46.1M | $28.3M | $10.7M | -$31.6M | -$629.0M |
| Retained Earnings | -$444.7M | -$463.7M | -$482.6M | -$649.2M | -$640.0B |
Cash Flow (Annual)
Last updated: Jun 27, 2026 12:02am (7h ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Operating Cash Flow | -$19.5M | -$16.3M | -$17.9M | -$3.0M | -$18.2B |
| Capital Expenditure | $0 | $0 | $-14,000 | $0 | $0 |
| Free Cash Flow | -$19.5M | -$16.3M | -$17.9M | -$3.0M | -$18.2B |
| Acquisitions (net) | $0 | $0 | $0 | $-364,800 | $0 |
| Debt Repayment | — | — | — | — | — |
| Dividends Paid | — | — | — | — | — |
| Stock Buybacks | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | $36.0M | -$16.3M | -$17.9M | $51,700 | -$17.5B |
Analyst Estimates (Annual)
Last updated: Jun 27, 2026 12:02am (7h ago)| Metric | 2025 | 2026 | 2027 | 2028 |
|---|---|---|---|---|
| Revenue |
$300,000 $300,000 – $300,000
|
$300,000 $300,000 – $300,000
|
$300,000 $300,000 – $300,000
|
$400,000 $400,000 – $400,000
|
| EBITDA |
$-300,000 $-300,000 – $-300,000
|
$-300,000 $-300,000 – $-300,000
|
$-300,000 $-300,000 – $-300,000
|
$-400,000 $-400,000 – $-400,000
|
| Net Income |
-$7.0M -$7.0M – -$7.0M
|
-$6.8M -$6.8M – -$6.8M
|
-$8.0M -$8.0M – -$8.0M
|
-$9.7M -$9.7M – -$9.7M
|
| EPS | — | — | — | — |
Growth Trends (YoY %)
Last updated: Jun 27, 2026 12:02am (7h ago)| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Revenue Growth | +0.0% | +0.0% | +0.0% | +1,234,413.3% |
| Gross Profit Growth | -6.2% | -100.0% | — | — |
| Operating Income Growth | -19.0% | -3.4% | -601.4% | -12,455.0% |
| Net Income Growth | -15.6% | -3.5% | +91.2% | +650.7% |
| EBITDA Growth | -15.1% | -7.0% | +100.0% | +5,083,233.3% |
Insider Trading (Recent)
Type codes
PPurchase
SSale
AAward / grant
MOption exercise
FIn-kind (tax)
CConversion
GGift
DReturn to issuer
All SEC Form 4 codes
Open market
- P Purchase
- Open-market or private purchase of shares.
- S Sale
- Open-market or private sale of shares.
Compensation (Rule 16b-3)
- A Award / grant
- Grant or award of securities (RSUs, options, etc.) under Rule 16b-3.
- D Return to issuer
- Securities disposed back to the company under Rule 16b-3.
- F In-kind (tax)
- Shares withheld or delivered to pay the option-exercise price or tax — not an open-market sale.
- I Discretionary
- Discretionary transaction under an employee plan — Rule 16b-3(f).
- M Option exercise
- Exercise or conversion of a derivative (option/RSU) into shares — exempt.
Derivatives
- C Conversion
- Conversion of a derivative security into the underlying shares.
- E Short expiration
- Expiration of a short derivative position.
- H Long expiration
- Expiration or cancellation of a long derivative position with value received.
- O OTM exercise
- Exercise of an out-of-the-money derivative.
- X ITM exercise
- Exercise of an in-the-money or at-the-money derivative.
Other exempt
- G Gift
- Bona fide gift of securities.
- L Small acquisition
- Small acquisition under Rule 16a-6.
- W Inheritance
- Acquisition or disposition by will or the laws of descent.
- Z Voting trust
- Deposit into or withdrawal from a voting trust.
Other
- J Other
- Other acquisition or disposition (explained in a Form 4 footnote).
- K Equity swap
- Transaction in an equity swap or similar instrument.
- U Tender / buyout
- Disposition via tender of shares in a change-of-control transaction.
Compensation-plan codes (A, D, F, M) are routine and rarely directional. Open-market P (buy) and S (sale) carry the most signal.
| Date | Insider | Type | Shares | Price | Value |
|---|---|---|---|---|---|
| 2024-03-13 | Guerin Mark Patrick | M-Exempt | 8,666.00 | $0.00 | $0 |
| 2024-03-14 | Guerin Mark Patrick | F-InKind | 2,591.00 | $0.90 | $2,332 |
| 2024-03-13 | Guerin Mark Patrick | M-Exempt | 8,666.00 | $0.00 | $0 |
| 2024-03-13 | Fruchtman Steven M | M-Exempt | 23,111.00 | $0.00 | $0 |
| 2024-03-14 | Fruchtman Steven M | F-InKind | 8,727.00 | $0.90 | $7,854 |
| 2024-03-13 | Fruchtman Steven M | M-Exempt | 23,111.00 | $0.00 | $0 |
| 2024-02-07 | Guerin Mark Patrick | M-Exempt | 6,900.00 | $0.00 | $0 |
| 2024-02-07 | Guerin Mark Patrick | F-InKind | 2,443.00 | $0.67 | $1,637 |
| 2024-02-07 | Guerin Mark Patrick | M-Exempt | 6,900.00 | $0.00 | $0 |
| 2024-02-07 | Fruchtman Steven M | M-Exempt | 21,320.00 | $0.00 | $0 |
| 2024-02-07 | Fruchtman Steven M | F-InKind | 9,212.00 | $0.67 | $6,172 |
| 2024-02-07 | Fruchtman Steven M | M-Exempt | 21,320.00 | $0.00 | $0 |
| 2023-10-02 | Moyo Victor M | A-Award | 125,000.00 | $0.74 | $92,500 |
| 2023-10-02 | Moyo Victor M | 0.00 | $0.00 | $0 | |
| 2023-08-10 | Shoemaker Mary Teresa | A-Award | 66,468.00 | $1.02 | $67,797 |
| 2023-08-10 | STOVER JACK E | A-Award | 66,468.00 | $1.02 | $67,797 |
| 2023-08-10 | Atadja Peter | A-Award | 66,468.00 | $1.02 | $67,797 |
| 2023-08-10 | Clarke Trafford | A-Award | 66,468.00 | $1.02 | $67,797 |
| 2023-08-10 | MEHTA VIREN | A-Award | 66,468.00 | $1.02 | $67,797 |
| 2023-08-10 | GROOPMAN JEROME | A-Award | 66,468.00 | $1.02 | $67,797 |
Narrative Economics
The story the market is telling about this stock — the intangible X-factor
(founder mythology, cult dynamics, TAM-of-imagination) that moves price beyond
what cash flows alone explain. After Shiller, Narrative Economics.
No narrative profile yet for ONTX — it's generated by the pipeline (
market-narrative step).
No community reviews yet for ONTX.
Be the first — hit How to Contribute, have any AI review this page, and paste its take back here.
My Notes
personal — only you see this
Sign in to save personal notes and rate your interest in this stock.
Data via Financial Modeling Prep · Cached for performance · fmp
v1.1.352 · d1100787 · 2026-06-26 11:39:30