Healthcare · Biotechnology
Price
$327.79
Market Cap
$6.9B
Employees
116
Beta
2.75
Avg Volume
460,008
CEO
Marcio Silva De'Souza
Business Description
Praxis Precision Medicines, Inc. is a biopharmaceutical firm operating at the clinical stage, dedicated to creating innovative treatments for central nervous system (CNS) conditions that stem from an imbalance in neuronal activity. The company's primary investigational compounds currently undergoing evaluation include: PRAX-114, an extrasynaptic-preferring positive allosteric modulator of the GABAA receptor, which is currently in Phase IIa clinical trials for addressing both major depressive disorder and perimenopausal depression. Additionally, PRAX-944, a small molecule designed to selectively inhibit T-type calcium channels, is also progressing through Phase IIa clinical trials to manage essential tremor. Beyond these, Praxis is also advancing a pipeline of other promising drug candidates, such as: PRAX-562, a persistent sodium current blocker, undergoing Phase I clinical evaluation for treating severe pediatric epilepsy and adult cephalgia (headaches). PRAX-222, an antisense oligonucleotide (ASO) aimed at individuals suffering from gain-of-function (GOF) SCN2A epilepsy. And a program targeting KCNT1 for the treatment of KCNT1 GOF epilepsy. To further its research and development efforts, Praxis maintains several strategic alliances. These include a cooperation and licensing arrangement with RogCon Inc.; a licensing deal with Purdue Neuroscience Company; a comprehensive research collaboration, option, and license agreement with Ionis Pharmaceuticals, Inc.; and a collaborative project with The Florey Institute focused on the creation of three new antisense oligonucleotides (ASOs). Established in 2015, the company's headquarters are situated in Boston, Massachusetts.
Business History
Price History (1 Year)
Revenue & Net Income Trend
The directional story — useful even when net income is negative.
Revenue
The top line — total sales before any costs or taxes are subtracted. A measure of how much business the company is doing.
Net Income
The bottom line — profit left after subtracting all expenses, interest, and taxes from revenue. Reflects accounting profitability, but includes non-cash items like depreciation, so it isn't the same as cash earned.
Operating Cash Flow
The real cash generated by the day-to-day business — selling products, paying suppliers, collecting from customers. Calculated from net income by adding back non-cash items and adjusting for timing (unpaid bills, unsold inventory). When OCF consistently lags net income, the reported profit may not be converting to real money.
| Period | Revenue | Net Income | Net Margin | YoY/QoQ |
|---|
Key Metrics
API Direct from provider
CALC Derived from statements
P/E Ratio (Price per dollar of earnings)
CALCStock Price / EPS (Diluted)
-24.32
Stock Price: $327.79
EPS (Diluted): -13.48
EPS (Diluted): -13.48
P/B Ratio (Price vs net asset value)
APIStock Price / Book Value Per Share
7.55
Stock Price: $327.79
Total Equity: $878.14M
Shares: 22,504,676
Total Equity: $878.14M
Shares: 22,504,676
EV/EBITDA (Total value vs operating profit)
APIEnterprise Value / EBITDA
-19.59
Market Cap: $6.93B
Total Debt: $0.00
Cash: $357.33M
EBITDA: -$303.13M
Total Debt: $0.00
Cash: $357.33M
EBITDA: -$303.13M
Enterprise Value (Takeover price (cap + debt - cash))
APIMarket Cap + Total Debt - Cash
$6.3B
Market Cap: $6.93B
Total Debt: $0.00
Cash: $357.33M
Total Debt: $0.00
Cash: $357.33M
P/S Ratio (Price per dollar of revenue)
APIStock Price / Revenue Per Share
0.00
Stock Price: $327.79
Revenue: $0.00
Shares: 22,504,676
Revenue: $0.00
Shares: 22,504,676
EV/Sales (Total value vs revenue — works when P/E can't)
API0.00
Gross Margin (Revenue left after direct costs)
APIGross Profit / Revenue
0.0%
Gross Profit: -$140,000
Revenue: $0.00
Revenue: $0.00
Operating Margin (Revenue left after all operations)
APIOperating Income / Revenue
0.0%
Operating Income: -$326.20M
Revenue: $0.00
Revenue: $0.00
Net Margin (Revenue left as actual profit)
APINet Income / Revenue
0.0%
Net Income: -$303.27M
Revenue: $0.00
Revenue: $0.00
ROE (Profit from shareholder equity)
APINet Income / Total Equity
-43.0%
Net Income: -$303.27M
Total Equity: $878.14M
Total Equity: $878.14M
ROIC (Profit from all invested capital)
APINOPAT / Invested Capital
-25.3%
Operating Income: -$326.20M
Tax Rate: 0.0%
Equity: $878.14M
Total Debt: $0.00
Cash: $357.33M
Tax Rate: 0.0%
Equity: $878.14M
Total Debt: $0.00
Cash: $357.33M
Zero debt — invested capital = equity minus cash (very efficient)
Current Ratio (Can it pay short-term bills)
APICurrent Assets / Current Liabilities
10.22
Current Assets: $610.91M
Current Liabilities: $59.77M
Current Liabilities: $59.77M
Debt/Equity (Leverage — debt vs equity)
CALCTotal Debt / Total Equity
0.00
Short-Term Debt: $0.00
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: $878.14M
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: $878.14M
Zero debt — this company carries no debt obligations. Strongest possible score.
Rev/Share (Top-line per share)
Revenue / Shares Outstanding
—
Revenue: $0.00
Shares: 22,504,676
Shares: 22,504,676
Book Value/Share (Net assets per share)
CALC(Total Assets - Total Liabilities) / Shares
$39.02
Total Equity: $878.14M
Shares: 22,504,676
Shares: 22,504,676
FCF/Share (Real cash generated per share)
CALC(Operating Cash Flow + CapEx) / Shares
$-11.07
Operating CF: -$249.07M
CapEx: -$56,000
Shares: 22,504,676
CapEx: -$56,000
Shares: 22,504,676
CapEx is negative (outflow) — added to OCF to get FCF
Div Yield (Annual income from holding)
APILast Annual Dividend / Stock Price
0.0%
Last Dividend: N/A
Stock Price: $327.79
Stock Price: $327.79
Payout Ratio (Earnings paid out as dividends)
Dividends Paid / Net Income
—
Dividends Paid: N/A
Net Income: -$303.27M
Net Income: -$303.27M
Dividends paid not available in cash flow statement
Industry Benchmarks
Compares PRAX against LLM-researched typical ranges for its
industry. One research call per industry, cached indefinitely — every stock in the same industry
reuses the same baseline.
Deep Analysis
Pre-flight intelligence scans the company first, then routes to the right analytical methods.
0
Company Classification
— What type of company is this?
1
Industry Landscape
— Where is the industry headed?
2
Company Momentum
— Where is this company trending?
3
Forward Projection
— 1Y & 2Y projected metrics (requires Layer 1 + 2)
4a
DCF Valuation
— Present value of future cash flows
4b
Earnings Power Value
— Floor value — worth with zero growth
4c
Anchored PE
— Industry PE adjusted for growth differential
4d
Reverse DCF
— What growth is the market pricing in?
4e
Revenue-Based DCF
— For growth/narrative companies (skip if mature earner)
4f
Anchored P/S
— Price-to-Sales peer comparison (skip if mature earner)
4g
Scenario Analysis
— Bull / Base / Bear (skip if mature earner)
4h
Dividend Discount Model
— For dividend/income stocks only
4i
Book Value Analysis
— For deep value / turnaround stocks only
4j
Insider Activity
— Are insiders buying or selling?
4f
Cash Flow Quality
— How trustworthy is the FCF?
4g
Debt Maturity Risk
— Can it handle its debt?
4h
Macro Environment
— Rates, market valuation, volatility
4i
Sector Intelligence
— How does this company compare within its sector?
4j
Revenue Confidence
— How reliable is the growth projection?
4k
Sensitivity Analysis
— How fragile is the fair value estimate?
4l
Sector Demand Cycle
— Is the sector in a boom, steady state, or contraction?
5
AI Investigation
— Adaptive research engine (Claude)
5b
Thesis Evaluation
— What does the market believe? (narrative/platform stocks only)
6
Valuation Synthesis
— Weighted verdict from all methods (requires Layer 4)
Income Statement (Annual)
Last updated: Jun 23, 2026 11:41pm (3d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Revenue | $0 | $0 | $2.4M | $8.6M | $0 |
| Cost of Revenue | $0 | $154.4M | $86.8M | $152.4M | $140,000 |
| Gross Profit | $0 | -$154.4M | -$84.3M | -$143.9M | $-140,000 |
| Operating Expenses | $167.3M | $60.5M | $42.1M | $56.3M | $326.1M |
| Operating Income | -$167.3M | -$215.0M | -$126.4M | -$200.2M | -$326.2M |
| Net Income | -$167.1M | -$214.0M | -$123.3M | -$182.8M | -$303.3M |
| EBITDA | -$166.9M | -$213.6M | -$122.8M | -$182.5M | -$303.1M |
| EPS | $-58.96 | $-69.33 | $-18.69 | $-10.21 | $-13.48 |
| EPS (Diluted) | — | — | — | — | — |
Balance Sheet (Annual)
Last updated: Jun 23, 2026 11:41pm (3d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Cash & Equivalents | $138.7M | $61.6M | $81.3M | $215.4M | $357.3M |
| Total Current Assets | $287.4M | $110.8M | $84.9M | $404.4M | $610.9M |
| Total Assets | $292.7M | $115.1M | $87.9M | $483.1M | $937.9M |
| Current Liabilities | $38.4M | $34.3M | $15.7M | $37.6M | $59.8M |
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $41.9M | $39.0M | $18.3M | $37.7M | $59.8M |
| Total Equity | $250.8M | $76.1M | $69.7M | $445.5M | $878.1M |
| Retained Earnings | -$316.6M | -$530.6M | -$653.9M | -$836.7M | -$1.1B |
Cash Flow (Annual)
Last updated: Jun 23, 2026 11:41pm (3d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Operating Cash Flow | -$124.6M | -$185.0M | -$111.1M | -$131.8M | -$249.1M |
| Capital Expenditure | -$1.1M | $-444,000 | $-50,000 | $0 | $-56,000 |
| Free Cash Flow | -$125.6M | -$185.5M | -$111.2M | -$131.8M | -$249.1M |
| Acquisitions (net) | $139.5M | -$97.3M | $0 | $0 | $0 |
| Debt Repayment | — | — | — | — | — |
| Dividends Paid | — | — | — | — | — |
| Stock Buybacks | $0 | $0 | $0 | $0 | $0 |
| Net Change in Cash | -$157.5M | -$77.7M | $19.7M | $134.1M | $142.0M |
Analyst Estimates (Annual)
Last updated: Jun 27, 2026 8:29am (1h ago)| Metric | 2027 | 2028 | 2029 | 2030 |
|---|---|---|---|---|
| Revenue |
$328.5M $164.4M – $423.3M
|
$1.1B $1.1B – $1.1B
|
$2.2B $1.0B – $3.6B
|
$3.5B $1.6B – $5.8B
|
| EBITDA |
$65.7M $32.9M – $84.7M
|
$219.5M $219.3M – $219.7M
|
$436.3M $201.1M – $727.3M
|
$690.9M $318.5M – $1.2B
|
| Net Income |
-$313.4M -$486.3M – -$55.3M
|
$230.8M -$266.5M – $684.6M
|
$662.7M $198.3M – $1.2B
|
$1.2B $349.5M – $2.2B
|
| EPS | — | — | — | — |
Growth Trends (YoY %)
Last updated: Jun 23, 2026 11:41pm (3d ago)| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Revenue Growth | — | — | +249.5% | -100.0% |
| Gross Profit Growth | — | +45.4% | -70.6% | +99.9% |
| Operating Income Growth | -28.5% | +41.2% | -58.4% | -63.0% |
| Net Income Growth | -28.1% | +42.4% | -48.3% | -65.9% |
| EBITDA Growth | -28.0% | +42.5% | -48.5% | -66.1% |
Insider Trading (Recent)
Last updated: Jun 27, 2026 8:29am (1h ago)
Type codes
PPurchase
SSale
AAward / grant
MOption exercise
FIn-kind (tax)
CConversion
GGift
DReturn to issuer
All SEC Form 4 codes
Open market
- P Purchase
- Open-market or private purchase of shares.
- S Sale
- Open-market or private sale of shares.
Compensation (Rule 16b-3)
- A Award / grant
- Grant or award of securities (RSUs, options, etc.) under Rule 16b-3.
- D Return to issuer
- Securities disposed back to the company under Rule 16b-3.
- F In-kind (tax)
- Shares withheld or delivered to pay the option-exercise price or tax — not an open-market sale.
- I Discretionary
- Discretionary transaction under an employee plan — Rule 16b-3(f).
- M Option exercise
- Exercise or conversion of a derivative (option/RSU) into shares — exempt.
Derivatives
- C Conversion
- Conversion of a derivative security into the underlying shares.
- E Short expiration
- Expiration of a short derivative position.
- H Long expiration
- Expiration or cancellation of a long derivative position with value received.
- O OTM exercise
- Exercise of an out-of-the-money derivative.
- X ITM exercise
- Exercise of an in-the-money or at-the-money derivative.
Other exempt
- G Gift
- Bona fide gift of securities.
- L Small acquisition
- Small acquisition under Rule 16a-6.
- W Inheritance
- Acquisition or disposition by will or the laws of descent.
- Z Voting trust
- Deposit into or withdrawal from a voting trust.
Other
- J Other
- Other acquisition or disposition (explained in a Form 4 footnote).
- K Equity swap
- Transaction in an equity swap or similar instrument.
- U Tender / buyout
- Disposition via tender of shares in a change-of-control transaction.
Compensation-plan codes (A, D, F, M) are routine and rarely directional. Open-market P (buy) and S (sale) carry the most signal.
| Date | Insider | Type | Shares | Price | Value |
|---|---|---|---|---|---|
| 2026-06-24 | DeSimone Jill | M-Exempt | 3,034.00 | $147.30 | $446,908 |
| 2026-06-24 | DeSimone Jill | S-Sale | 10.00 | $301.44 | $3,014 |
| 2026-06-24 | DeSimone Jill | S-Sale | 120.00 | $303.13 | $36,375 |
| 2026-06-24 | DeSimone Jill | S-Sale | 320.00 | $305.31 | $97,699 |
| 2026-06-24 | DeSimone Jill | S-Sale | 683.00 | $306.77 | $209,522 |
| 2026-06-24 | DeSimone Jill | S-Sale | 1,240.00 | $308.24 | $382,221 |
| 2026-06-24 | DeSimone Jill | M-Exempt | 8,566.00 | $44.25 | $379,046 |
| 2026-06-24 | DeSimone Jill | S-Sale | 999.00 | $309.38 | $309,074 |
| 2026-06-24 | DeSimone Jill | S-Sale | 1,750.00 | $310.89 | $544,056 |
| 2026-06-24 | DeSimone Jill | S-Sale | 2,854.00 | $311.91 | $890,203 |
| 2026-06-24 | DeSimone Jill | S-Sale | 1,004.00 | $312.83 | $314,081 |
| 2026-06-24 | DeSimone Jill | S-Sale | 504.00 | $313.66 | $158,086 |
| 2026-06-24 | DeSimone Jill | S-Sale | 1,279.00 | $314.90 | $402,758 |
| 2026-06-24 | DeSimone Jill | S-Sale | 837.00 | $315.71 | $264,245 |
| 2026-06-24 | DeSimone Jill | M-Exempt | 8,566.00 | $44.25 | $379,046 |
| 2026-06-24 | DeSimone Jill | M-Exempt | 3,034.00 | $147.30 | $446,908 |
| 2026-06-10 | Arbuckle Stuart A | A-Award | 1,371.00 | $0.00 | $0 |
| 2026-06-10 | Arbuckle Stuart A | A-Award | 648.00 | $240.66 | $155,948 |
| 2026-06-10 | Chodakewitz Jeffrey | A-Award | 1,371.00 | $0.00 | $0 |
| 2026-06-10 | Chodakewitz Jeffrey | A-Award | 648.00 | $240.66 | $155,948 |
Narrative Economics
The story the market is telling about this stock — the intangible X-factor
(founder mythology, cult dynamics, TAM-of-imagination) that moves price beyond
what cash flows alone explain. After Shiller, Narrative Economics.
No narrative profile yet for PRAX — it's generated by the pipeline (
market-narrative step).
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My Notes
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Data via Financial Modeling Prep · Cached for performance · fmp
v1.1.352 · d1100787 · 2026-06-26 11:39:30