Healthcare · Biotechnology
Price
$0.68
Market Cap
$8.0M
Employees
1
Beta
0.52
Avg Volume
11,756
CEO
Mary Beth Dooley
Business Description
Operating as a clinical-stage biopharmaceutical enterprise, Synlogic, Inc. is dedicated to the creation and progression of synthetic biotic therapeutics aimed at addressing metabolic and immunological conditions across the United States. Its robust portfolio features multiple drug candidates: SYNB1618 and SYNB1934, both non-systemically absorbed and orally administered, are progressing through Phase II clinical trials for phenylketonuria. Another oral, non-systemic agent, SYNB1353, is designed to treat homocystinuria. Furthermore, SYNB8802, an orally taken, non-systemic compound, is currently in Phase I trials for managing enteric hyperoxaluria. Beyond oral treatments, the company is also developing SYNB1891, an intratumorally delivered synthetic biotic medicine undergoing Phase I investigation for solid tumors and lymphoma. Synlogic, Inc. has established partnerships with F. Hoffmann-La Roche Ltd, Hoffmann-La Roche Inc., and Ginkgo Bioworks, Inc., and its main office is located in Cambridge, Massachusetts.
Business History
Price Overview
Last updated: Jun 27, 2026 10:06am (just now)$0.68
+0.00 (+0.44%)
Day Range
$0.61 – $0.68
52-Week Range
$0.54 – $1.96
50-Day MA
$0.67
200-Day MA
$1.02
Volume
768.00
Share Structure
Outstanding
11,696,641.00
Float
7,095,499.00
Free Float
60.7%
Normal free float
— 60.7% of shares trade freely, ~39.3% held by insiders/institutions
Healthy float typical of established companies. Good liquidity for entering and exiting positions without major price impact.
Small absolute float (7.1M shares) — even with a decent free float %, volume can be thin. Check average daily volume before sizing a position.
Price History (1 Year)
Revenue & Net Income Trend
The directional story — useful even when net income is negative.
Revenue
The top line — total sales before any costs or taxes are subtracted. A measure of how much business the company is doing.
Net Income
The bottom line — profit left after subtracting all expenses, interest, and taxes from revenue. Reflects accounting profitability, but includes non-cash items like depreciation, so it isn't the same as cash earned.
Operating Cash Flow
The real cash generated by the day-to-day business — selling products, paying suppliers, collecting from customers. Calculated from net income by adding back non-cash items and adjusting for timing (unpaid bills, unsold inventory). When OCF consistently lags net income, the reported profit may not be converting to real money.
| Period | Revenue | Net Income | Net Margin | YoY/QoQ |
|---|
Key Metrics
API Direct from provider
CALC Derived from statements
P/E Ratio (Price per dollar of earnings)
CALCStock Price / EPS (Diluted)
-8.50
Stock Price: $0.68
EPS (Diluted): -0.08
EPS (Diluted): -0.08
P/B Ratio (Price vs net asset value)
APIStock Price / Book Value Per Share
1.16
Stock Price: $0.68
Total Equity: $11.86M
Shares: 12,311,909
Total Equity: $11.86M
Shares: 12,311,909
EV/EBITDA (Total value vs operating profit)
APIEnterprise Value / EBITDA
1.68
Market Cap: $7.95M
Total Debt: $0.00
Cash: $14.67M
EBITDA: -$3.53M
Total Debt: $0.00
Cash: $14.67M
EBITDA: -$3.53M
Enterprise Value (Takeover price (cap + debt - cash))
APIMarket Cap + Total Debt - Cash
$-878,662
Market Cap: $7.95M
Total Debt: $0.00
Cash: $14.67M
Total Debt: $0.00
Cash: $14.67M
P/S Ratio (Price per dollar of revenue)
APIStock Price / Revenue Per Share
0.00
Stock Price: $0.68
Revenue: $0.00
Shares: 12,311,909
Revenue: $0.00
Shares: 12,311,909
EV/Sales (Total value vs revenue — works when P/E can't)
API0.00
Gross Margin (Revenue left after direct costs)
APIGross Profit / Revenue
0.0%
Gross Profit: $0.00
Revenue: $0.00
Revenue: $0.00
Operating Margin (Revenue left after all operations)
APIOperating Income / Revenue
0.0%
Operating Income: -$4.01M
Revenue: $0.00
Revenue: $0.00
Net Margin (Revenue left as actual profit)
APINet Income / Revenue
0.0%
Net Income: -$1.01M
Revenue: $0.00
Revenue: $0.00
ROE (Profit from shareholder equity)
APINet Income / Total Equity
-5.4%
Net Income: -$1.01M
Total Equity: $11.86M
Total Equity: $11.86M
ROIC (Profit from all invested capital)
APINOPAT / Invested Capital
-36.8%
Operating Income: -$4.01M
Tax Rate: 0.0%
Equity: $11.86M
Total Debt: $0.00
Cash: $14.67M
Tax Rate: 0.0%
Equity: $11.86M
Total Debt: $0.00
Cash: $14.67M
Zero debt — invested capital = equity minus cash (very efficient)
Current Ratio (Can it pay short-term bills)
APICurrent Assets / Current Liabilities
4.30
Current Assets: $15.40M
Current Liabilities: $3.58M
Current Liabilities: $3.58M
Debt/Equity (Leverage — debt vs equity)
CALCTotal Debt / Total Equity
0.00
Short-Term Debt: $0.00
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: $11.86M
Long-Term Debt: $0.00
Total Debt: $0.00
Total Equity: $11.86M
Zero debt — this company carries no debt obligations. Strongest possible score.
Rev/Share (Top-line per share)
Revenue / Shares Outstanding
—
Revenue: $0.00
Shares: 12,311,909
Shares: 12,311,909
Book Value/Share (Net assets per share)
CALC(Total Assets - Total Liabilities) / Shares
$0.96
Total Equity: $11.86M
Shares: 12,311,909
Shares: 12,311,909
FCF/Share (Real cash generated per share)
CALC(Operating Cash Flow + CapEx) / Shares
$-0.35
Operating CF: -$4.36M
CapEx: $0.00
Shares: 12,311,909
CapEx: $0.00
Shares: 12,311,909
Div Yield (Annual income from holding)
APILast Annual Dividend / Stock Price
0.0%
Last Dividend: N/A
Stock Price: $0.68
Stock Price: $0.68
Payout Ratio (Earnings paid out as dividends)
Dividends Paid / Net Income
—
Dividends Paid: N/A
Net Income: -$1.01M
Net Income: -$1.01M
Dividends paid not available in cash flow statement
Industry Benchmarks
Compares SYBX against LLM-researched typical ranges for its
industry. One research call per industry, cached indefinitely — every stock in the same industry
reuses the same baseline.
Deep Analysis
Pre-flight intelligence scans the company first, then routes to the right analytical methods.
0
Company Classification
— What type of company is this?
1
Industry Landscape
— Where is the industry headed?
2
Company Momentum
— Where is this company trending?
3
Forward Projection
— 1Y & 2Y projected metrics (requires Layer 1 + 2)
4a
DCF Valuation
— Present value of future cash flows
4b
Earnings Power Value
— Floor value — worth with zero growth
4c
Anchored PE
— Industry PE adjusted for growth differential
4d
Reverse DCF
— What growth is the market pricing in?
4e
Revenue-Based DCF
— For growth/narrative companies (skip if mature earner)
4f
Anchored P/S
— Price-to-Sales peer comparison (skip if mature earner)
4g
Scenario Analysis
— Bull / Base / Bear (skip if mature earner)
4h
Dividend Discount Model
— For dividend/income stocks only
4i
Book Value Analysis
— For deep value / turnaround stocks only
4j
Insider Activity
— Are insiders buying or selling?
4f
Cash Flow Quality
— How trustworthy is the FCF?
4g
Debt Maturity Risk
— Can it handle its debt?
4h
Macro Environment
— Rates, market valuation, volatility
4i
Sector Intelligence
— How does this company compare within its sector?
4j
Revenue Confidence
— How reliable is the growth projection?
4k
Sensitivity Analysis
— How fragile is the fair value estimate?
4l
Sector Demand Cycle
— Is the sector in a boom, steady state, or contraction?
5
AI Investigation
— Adaptive research engine (Claude)
5b
Thesis Evaluation
— What does the market believe? (narrative/platform stocks only)
6
Valuation Synthesis
— Weighted verdict from all methods (requires Layer 4)
Income Statement (Annual)
Last updated: Jun 26, 2026 10:03am (1d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Revenue | $1.8M | $1.2M | $3.4M | $8,000 | $0 |
| Cost of Revenue | $0 | $0 | $0 | $0 | $0 |
| Gross Profit | $1.8M | $1.2M | $3.4M | $8,000 | $0 |
| Operating Expenses | $62.5M | $68.6M | $58.5M | $41.0M | $4.0M |
| Operating Income | -$60.8M | -$67.4M | -$55.2M | -$41.0M | -$4.0M |
| Net Income | -$60.6M | -$66.1M | -$57.3M | -$23.4M | -$1.0M |
| EBITDA | -$58.1M | -$63.6M | -$55.3M | -$22.1M | -$3.5M |
| EPS | $-15.76 | $-13.57 | $-8.81 | $-1.92 | $-0.08 |
| EPS (Diluted) | — | — | — | — | — |
Balance Sheet (Annual)
Last updated: Jun 26, 2026 10:03am (1d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Cash & Equivalents | $16.4M | $15.9M | $24.0M | $18.9M | $14.7M |
| Total Current Assets | $133.3M | $79.8M | $49.9M | $19.8M | $15.4M |
| Total Assets | $174.7M | $110.9M | $75.6M | $19.8M | $15.4M |
| Current Liabilities | $10.1M | $12.1M | $20.4M | $7.1M | $3.6M |
| Long-Term Debt | $0 | $0 | $0 | $0 | $0 |
| Total Liabilities | $27.5M | $28.3M | $32.9M | $7.1M | $3.6M |
| Total Equity | $147.3M | $82.6M | $42.7M | $12.8M | $11.9M |
| Retained Earnings | -$290.9M | -$357.0M | -$414.3M | -$441.7M | -$442.7M |
Cash Flow (Annual)
Last updated: Jun 26, 2026 10:03am (1d ago)| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Operating Cash Flow | -$52.2M | -$56.9M | -$51.6M | -$31.7M | -$4.4M |
| Capital Expenditure | $-679,000 | $-728,000 | $-214,000 | $-14,000 | $0 |
| Free Cash Flow | -$52.9M | -$57.6M | -$51.8M | -$31.7M | -$4.4M |
| Acquisitions (net) | -$1.3M | $0 | $0 | $0 | $0 |
| Debt Repayment | — | — | — | — | — |
| Dividends Paid | — | — | — | — | — |
| Stock Buybacks | $0 | -$2.5M | $0 | $0 | $0 |
| Net Change in Cash | -$16.1M | $-577,000 | $8.1M | -$6.1M | -$4.2M |
Analyst Estimates (Annual)
Last updated: Jun 27, 2026 10:06am (just now)| Metric | 2025 | 2026 | 2027 | 2028 |
|---|---|---|---|---|
| Revenue |
$4.5M $4.5M – $4.5M
|
$22.8M $22.8M – $22.8M
|
$83.2M $83.2M – $83.2M
|
$233.0M $233.0M – $233.0M
|
| EBITDA |
-$2.7M -$2.7M – -$2.7M
|
-$13.7M -$13.7M – -$13.7M
|
-$49.9M -$49.9M – -$49.9M
|
-$139.8M -$139.8M – -$139.8M
|
| Net Income |
-$5.8M -$5.8M – -$5.8M
|
-$2.8M -$2.8M – -$2.8M
|
-$15.1M -$15.1M – -$15.1M
|
$75.6M $75.6M – $75.6M
|
| EPS | — | — | — | — |
Growth Trends (YoY %)
Last updated: Jun 26, 2026 10:03am (1d ago)| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Revenue Growth | -32.7% | +185.7% | -99.8% | -100.0% |
| Gross Profit Growth | -32.7% | +185.7% | -99.8% | -100.0% |
| Operating Income Growth | -11.0% | +18.2% | +25.8% | +90.2% |
| Net Income Growth | -9.2% | +13.4% | +59.2% | +95.7% |
| EBITDA Growth | -9.5% | +13.1% | +60.1% | +84.0% |
Insider Trading (Recent)
Type codes
PPurchase
SSale
AAward / grant
MOption exercise
FIn-kind (tax)
CConversion
GGift
DReturn to issuer
All SEC Form 4 codes
Open market
- P Purchase
- Open-market or private purchase of shares.
- S Sale
- Open-market or private sale of shares.
Compensation (Rule 16b-3)
- A Award / grant
- Grant or award of securities (RSUs, options, etc.) under Rule 16b-3.
- D Return to issuer
- Securities disposed back to the company under Rule 16b-3.
- F In-kind (tax)
- Shares withheld or delivered to pay the option-exercise price or tax — not an open-market sale.
- I Discretionary
- Discretionary transaction under an employee plan — Rule 16b-3(f).
- M Option exercise
- Exercise or conversion of a derivative (option/RSU) into shares — exempt.
Derivatives
- C Conversion
- Conversion of a derivative security into the underlying shares.
- E Short expiration
- Expiration of a short derivative position.
- H Long expiration
- Expiration or cancellation of a long derivative position with value received.
- O OTM exercise
- Exercise of an out-of-the-money derivative.
- X ITM exercise
- Exercise of an in-the-money or at-the-money derivative.
Other exempt
- G Gift
- Bona fide gift of securities.
- L Small acquisition
- Small acquisition under Rule 16a-6.
- W Inheritance
- Acquisition or disposition by will or the laws of descent.
- Z Voting trust
- Deposit into or withdrawal from a voting trust.
Other
- J Other
- Other acquisition or disposition (explained in a Form 4 footnote).
- K Equity swap
- Transaction in an equity swap or similar instrument.
- U Tender / buyout
- Disposition via tender of shares in a change-of-control transaction.
Compensation-plan codes (A, D, F, M) are routine and rarely directional. Open-market P (buy) and S (sale) carry the most signal.
| Date | Insider | Type | Shares | Price | Value |
|---|---|---|---|---|---|
| 2025-10-29 | Dooley Mary Beth | S-Sale | 157.00 | $1.81 | $284 |
| 2025-04-26 | Shea Richard P | A-Award | 15,000.00 | $0.00 | $0 |
| 2025-04-26 | Flynn James P | A-Award | 15,000.00 | $0.00 | $0 |
| 2025-04-02 | Dooley Mary Beth | S-Sale | 144.00 | $1.20 | $173 |
| 2025-02-03 | Dooley Mary Beth | S-Sale | 2,107.00 | $1.33 | $2,802 |
| 2024-10-29 | Dooley Mary Beth | S-Sale | 79.00 | $1.40 | $111 |
| 2024-04-02 | Dooley Mary Beth | S-Sale | 188.00 | $1.73 | $325 |
| 2024-04-02 | Awad Antoine | S-Sale | 372.00 | $1.73 | $644 |
| 2024-03-18 | Dooley Mary Beth | 0.00 | $0.00 | $0 | |
| 2024-03-18 | Dooley Mary Beth | 3,612.00 | $1.85 | $6,682 | |
| 2024-03-19 | Flynn James P | A-Award | 4,000.00 | $1.78 | $7,120 |
| 2024-03-19 | Flynn James P | 0.00 | $0.00 | $0 | |
| 2024-02-09 | Funicular Funds, LP | 0.00 | $0.00 | $0 | |
| 2024-01-02 | Hurter Patricia N. | A-Award | 14,678.00 | $4.47 | $65,611 |
| 2024-01-02 | Barrett Peter | A-Award | 24,923.00 | $4.47 | $111,406 |
| 2023-11-10 | Brennan Aoife | A-Award | 42,999.00 | $1.85 | $79,548 |
| 2023-11-10 | Brennan Aoife | A-Award | 28,943.00 | $1.85 | $53,545 |
| 2023-11-10 | Brennan Aoife | A-Award | 18,999.00 | $1.85 | $35,148 |
| 2023-11-10 | Brennan Aoife | A-Award | 12,352.00 | $1.85 | $22,851 |
| 2023-11-10 | Brennan Aoife | A-Award | 12,332.00 | $1.85 | $22,814 |
Narrative Economics
The story the market is telling about this stock — the intangible X-factor
(founder mythology, cult dynamics, TAM-of-imagination) that moves price beyond
what cash flows alone explain. After Shiller, Narrative Economics.
No narrative profile yet for SYBX — it's generated by the pipeline (
market-narrative step).
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Data via Financial Modeling Prep · Cached for performance · fmp
v1.1.352 · d1100787 · 2026-06-26 11:39:30