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aTyr Pharma, Inc.

ATYR NASDAQ Categories PDF
Healthcare · Biotechnology · United States · Updated May 11, 1:53pm
$0.96
Price
$94.2M
Market Cap
56
Employees
0.66
Beta
Sanjay S. Shukla
CEO
Business Description

aTyr Pharma, Inc., a biotherapeutics company, engages in the discovery and development of medicines based on novel immunological pathways in the United States. Its lead therapeutic candidate is efzofitimod, a selective modulator of NRP2 that is in Phase III clinical trial for pulmonary sarcoidosis; and in Phase 1b/2a clinical trial for treatment of other interstitial lung diseases (ILDs), such as chronic hypersensitivity pneumonitis and connective tissue disease related ILD. The company is developing ATYR0101, a fusion protein derived from a domain of aspartyl-tRNA synthetase that is in preclinical development for the treatment of fibrosis; and ATYR0750, a domain of alanyl-tRNA synthetase for the treatment of liver disorders. It has collaboration and license agreement with Kyorin Pharmaceutical Co., Ltd. for the development and commercialization of efzofitimod for ILDs in Japan. aTyr Pharma, Inc. was incorporated in 2005 and is headquartered in San Diego, California.

Business History
Price Overview
Last updated: May 11, 2026 1:53pm (just now)
$0.96
+0.01 (+1.49%)
Day Range
$0.93 – $0.99
52-Week Range
$0.64 – $7.29
50-Day MA
$0.85
200-Day MA
$1.64
Volume
57,272.00
Analyst Price Targets
Low $1.00
Consensus $5.13
High $17.00
(4 analysts)
Share Structure
Outstanding 98,051,200.00
Float 95,610,717.00
Free Float 97.5%
High free float — 97.5% of shares trade freely, ~2.5% held by insiders/institutions
Very liquid — most shares trade freely. Low insider ownership can mean less management alignment, but makes large position sizing straightforward.
Price History (1 Year)
Revenue & Net Income Trend
The directional story — useful even when net income is negative.
Revenue
The top line — total sales before any costs or taxes are subtracted. A measure of how much business the company is doing.
Net Income
The bottom line — profit left after subtracting all expenses, interest, and taxes from revenue. Reflects accounting profitability, but includes non-cash items like depreciation, so it isn't the same as cash earned.
Operating Cash Flow
The real cash generated by the day-to-day business — selling products, paying suppliers, collecting from customers. Calculated from net income by adding back non-cash items and adjusting for timing (unpaid bills, unsold inventory). When OCF consistently lags net income, the reported profit may not be converting to real money.
Period Revenue Net Income Net Margin YoY/QoQ
Key Metrics
API Direct from provider CALC Derived from statements
P/E Ratio (Price per dollar of earnings)
CALC
Stock Price / EPS (Diluted)
-1.20
Stock Price: $0.96
EPS (Diluted): -0.80
P/B Ratio (Price vs net asset value)
API
Stock Price / Book Value Per Share
1.08
Stock Price: $0.96
Total Equity: $67.48M
Shares: 92,985,359
EV/EBITDA (Total value vs operating profit)
API
Enterprise Value / EBITDA
-1.27
Market Cap: $94.17M
Total Debt: $1.47M
Cash: $10.74M
EBITDA: -$76.07M
Enterprise Value (Takeover price (cap + debt - cash))
API
Market Cap + Total Debt - Cash
$74.1M
Market Cap: $94.17M
Total Debt: $1.47M
Cash: $10.74M
Gross Margin (Revenue left after direct costs)
API
Gross Profit / Revenue
-717.4%
Gross Profit: -$1.36M
Revenue: $190,000
Operating Margin (Revenue left after all operations)
API
Operating Income / Revenue
-40,856.3%
Operating Income: -$77.63M
Revenue: $190,000
Net Margin (Revenue left as actual profit)
API
Net Income / Revenue
-39,009.5%
Net Income: -$74.12M
Revenue: $190,000
ROE (Profit from shareholder equity)
API
Net Income / Total Equity
-99.6%
Net Income: -$74.12M
Total Equity: $67.48M
ROIC (Profit from all invested capital)
API
NOPAT / Invested Capital
-96.5%
Operating Income: -$77.63M
Tax Rate: 0.0%
Equity: $67.48M
Total Debt: $1.47M
Cash: $10.74M
Current Ratio (Can it pay short-term bills)
API
Current Assets / Current Liabilities
5.30
Current Assets: $80.24M
Current Liabilities: $15.15M
Debt/Equity (Leverage — debt vs equity)
CALC
Total Debt / Total Equity
0.02
Short-Term Debt: $1.47M
Long-Term Debt: $0.00
Total Debt: $1.47M
Total Equity: $67.48M
Rev/Share (Top-line per share)
CALC
Revenue / Shares Outstanding
$0.00
Revenue: $190,000
Shares: 92,985,359
Book Value/Share (Net assets per share)
CALC
(Total Assets - Total Liabilities) / Shares
$0.73
Total Equity: $67.48M
Shares: 92,985,359
FCF/Share (Real cash generated per share)
CALC
(Operating Cash Flow + CapEx) / Shares
$-0.67
Operating CF: -$61.99M
CapEx: -$77,000
Shares: 92,985,359
CapEx is negative (outflow) — added to OCF to get FCF
Div Yield (Annual income from holding)
API
Last Annual Dividend / Stock Price
0.0%
Last Dividend: N/A
Stock Price: $0.96
Payout Ratio (Earnings paid out as dividends)
Dividends Paid / Net Income
—
Dividends Paid: N/A
Net Income: -$74.12M
Dividends paid not available in cash flow statement
Industry Benchmarks
Compares ATYR against LLM-researched typical ranges for its industry. One research call per industry, cached indefinitely — every stock in the same industry reuses the same baseline.
Deep Analysis

Pre-flight intelligence scans the company first, then routes to the right analytical methods.

0 Company Classification — What type of company is this?
1 Industry Landscape — Where is the industry headed?
2 Company Momentum — Where is this company trending?
3 Forward Projection — 1Y & 2Y projected metrics (requires Layer 1 + 2)
4a DCF Valuation — Present value of future cash flows
4b Earnings Power Value — Floor value — worth with zero growth
4c Anchored PE — Industry PE adjusted for growth differential
4d Reverse DCF — What growth is the market pricing in?
4e Revenue-Based DCF — For growth/narrative companies (skip if mature earner)
4f Anchored P/S — Price-to-Sales peer comparison (skip if mature earner)
4g Scenario Analysis — Bull / Base / Bear (skip if mature earner)
4h Dividend Discount Model — For dividend/income stocks only
4i Book Value Analysis — For deep value / turnaround stocks only
4j Insider Activity — Are insiders buying or selling?
4f Cash Flow Quality — How trustworthy is the FCF?
4g Debt Maturity Risk — Can it handle its debt?
4h Macro Environment — Rates, market valuation, volatility
4i Sector Intelligence — How does this company compare within its sector?
4j Revenue Confidence — How reliable is the growth projection?
4k Sensitivity Analysis — How fragile is the fair value estimate?
4l Sector Demand Cycle — Is the sector in a boom, steady state, or contraction?
5 AI Investigation — Adaptive research engine (Claude)
5b Thesis Evaluation — What does the market believe? (narrative/platform stocks only)
6 Valuation Synthesis — Weighted verdict from all methods (requires Layer 4)
Income Statement (Annual)
Metric 2021 2022 2023 2024 2025
Revenue $0 $10.4M $353,000 $235,000 $190,000
Cost of Revenue $1.3M $1.7M $0 $0 $1.6M
Gross Profit -$1.3M $8.7M $353,000 $235,000 -$1.4M
Operating Expenses $32.7M $55.1M $55.3M $68.1M $76.3M
Operating Income -$34.0M -$46.4M -$54.9M -$67.9M -$77.6M
Net Income -$33.8M -$45.3M -$50.4M -$64.0M -$74.1M
EBITDA -$32.5M -$44.7M -$52.2M -$66.4M -$76.1M
EPS $-1.77 $-1.60 $-0.94 $-0.86 $-0.80
EPS (Diluted) — — — — —
Balance Sheet (Annual)
Metric 2021 2022 2023 2024 2025
Cash & Equivalents $2.3M $10.0M $22.5M $11.1M $10.7M
Total Current Assets $113.6M $80.9M $103.0M $82.0M $80.2M
Total Assets $115.5M $95.8M $120.7M $96.8M $94.2M
Current Liabilities $6.0M $13.9M $16.4M $15.0M $15.1M
Long-Term Debt $0 $0 $0 $0 $0
Total Liabilities $6.4M $24.5M $30.2M $27.0M $26.9M
Total Equity $109.3M $71.5M $90.7M $70.0M $67.5M
Retained Earnings -$372.3M -$417.6M -$468.0M -$532.0M -$606.2M
Cash Flow (Annual)
Metric 2021 2022 2023 2024 2025
Operating Cash Flow -$33.1M -$41.9M -$33.2M -$69.1M -$62.0M
Capital Expenditure $-192,000 -$1.6M -$4.2M $-65,000 $-77,000
Free Cash Flow -$33.3M -$43.5M -$37.4M -$69.2M -$62.1M
Acquisitions (net) $50,000 $0 $0 $7,000 $12,000
Debt Repayment — — — — —
Dividends Paid — — — — —
Stock Buybacks $0 $0 $0 $0 $0
Net Change in Cash -$14.6M $10.8M $12.9M -$12.0M -$1.0M
Analyst Estimates (Annual)
Metric 2027 2028 2029 2030
Revenue $8.8M
$8.8M – $8.8M
 $40.3M
$40.3M – $40.3M
 $156.0M
$156.0M – $156.0M
 $313.0M
$313.0M – $313.0M
EBITDA -$5.3M
-$5.3M – -$5.3M
 -$24.2M
-$24.2M – -$24.2M
 -$93.6M
-$93.6M – -$93.6M
 -$187.8M
-$187.8M – -$187.8M
Net Income -$49.9M
-$64.9M – -$10.8M
 -$33.5M
-$55.3M – $95.2M
 $57.4M
$57.4M – $57.4M
 $135.8M
$135.8M – $135.8M
EPS — — — —
Growth Trends (YoY %)
Metric 2022 2023 2024 2025
Revenue Growth — -96.6% -33.4% -19.1%
Gross Profit Growth +766.5% -95.9% -33.4% -680.0%
Operating Income Growth -36.4% -18.3% -23.7% -14.3%
Net Income Growth -34.3% -11.1% -27.1% -15.8%
EBITDA Growth -37.7% -16.7% -27.2% -14.6%
Insider Trading (Recent)
Date Insider Type Shares Price Value
2026-02-03 Shukla Sanjay M-Exempt 10,375.00 $0.00 $0
2026-02-04 Shukla Sanjay S-Sale 3,745.00 $0.98 $3,655
2026-02-03 Shukla Sanjay M-Exempt 10,375.00 $0.00 $0
2026-02-03 Broadfoot Jill Marie M-Exempt 3,750.00 $0.00 $0
2026-02-04 Broadfoot Jill Marie S-Sale 1,558.00 $0.98 $1,521
2026-02-03 Broadfoot Jill Marie M-Exempt 3,750.00 $0.00 $0
2026-02-03 DENYES NANCY M-Exempt 2,687.00 $0.00 $0
2026-02-04 DENYES NANCY S-Sale 1,118.00 $0.98 $1,091
2026-02-03 DENYES NANCY M-Exempt 2,687.00 $0.00 $0
2026-01-09 Shukla Sanjay A-Award 1,500,000.00 $0.71 $1.1M
2026-01-09 Broadfoot Jill Marie A-Award 412,500.00 $0.71 $293,989
2026-01-09 DENYES NANCY A-Award 412,500.00 $0.71 $293,989
2025-10-09 SCHIMMEL PAUL P-Purchase 317,999.00 $0.94 $299,364
2025-10-08 SCHIMMEL PAUL P-Purchase 682,001.00 $0.90 $612,437
2025-05-01 Zaknoen Sara A-Award 50,000.00 $3.34 $167,000
2025-05-01 SCHIMMEL PAUL A-Award 50,000.00 $3.34 $167,000
2025-05-01 Lucas Svetlana A-Award 50,000.00 $3.34 $167,000
2025-05-01 Gross Jane A A-Award 50,000.00 $3.34 $167,000
2025-05-01 BENEVICH ERIC A-Award 50,000.00 $3.34 $167,000
2025-05-01 COUGHLIN TIMOTHY A-Award 50,000.00 $3.34 $167,000
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My Notes personal — only you see this
Data via Financial Modeling Prep · Cached for performance · fmp
v1.1.193 · 1946f027 · 2026-05-08 18:57:27